The essential oils in PhenoDerma’s Pain Relief Cream help to relax and soften the skin so that the CBD can permeate the skin’s outer layer. Massaging the cream into the skin for a couple of minutes helps with this process. Once the cream’s active ingredients pass through the epidermis, the CBD is picked up by cannabinoid receptors within the skin and activates the body’s endocannabinoid system, relieving inflammation deep below the skin.